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The catch, however, is that Ross and his team are still figuring out how exactly their drug works. When the researchers put the drug into mice with myelofibrosis, a form of blood cancer where scar tissue builds up in the bone marrow, they saw that all the mice treated with their drug survived to 28 days after treatment - the planned cutoff for the study - while control group mice had progressive disease, “reaching humane endpoints” before 21 days. “The drug is filling up this big reservoir - it’s being sequestered away from the entire body by the absorption, and then slowly draining over a day into a neck vein.”Īnd that slow drip from the lymphatic system means that the drug doesn’t cause an initial spike like traditional oral drugs.
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Instead, the lymph nodes were “sort of like a gas can that you fill up in your car,” Ross said. The broken-down parts of those drugs can contribute to liver damage, but their drug avoided that by going through the lymph system, according to Ross. Most oral drugs are absorbed through the blood, meaning they first pass through the liver, where some drugs are metabolized. “To my mind, it’s the world’s first kinase inhibitor that’s lymphatically absorbed,” he said. “It was quite astonishing, actually.” So we retooled the group, retooled the lab … and we found it, in fact, was lymphatically absorbed,” Ross said. “After talking to colleagues, we thought perhaps this is a lymphatically absorbed drug. But when it came to this drug, a PI3K and MAPK inhibitor dubbed LP-182, they noticed it was behaving differently and that it was being absorbed at a different rate. You may need to repair these installations if the error continues and you have tried all of the steps above.Over those six years, Ross’ lab has been looking at unconventional structures for and publishing about multifunctional inhibitors.
COOLTERM 104 FRAMING ERROR SERIAL
This is unlikely, but to use serial devices you need to have LabVIEW, NI-Serial, and NI-VISA on your computer. Move the serial cable way from power cables, monitors, or other potential noise sources. You may be experiencing noise on your serial line. Refer to the article: Should I Use Null Modem or Straight Through Serial Cables?į.
COOLTERM 104 FRAMING ERROR MANUAL
Try another serial cable and check your device manual to determine if a null modem or straight through cable is required. You may have a bad serial cable or the wrong type of serial cable. Check to make sure your cables are securely plugged in.Į. Note: You can change these settings programmatically during run-time as seen in the example above, or in NI-MAX as in the example below.ĭ. The easiest way to check the configuration is by tracing the received signal with an oscilloscope. Verify that the VISA Resource Name, Baud rate, Data bits, Parity, and Stop bits all match the settings of your device under the port settings tab.
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To solve this issue, open NI Measurement & Automation Explorer (NI MAX) and select your serial port under Devices and Interfaces. Your serial port and device may be configured to use different settings. You may be closing the VISA Resource before the Read/Write task is complete.Ĭ. Your block diagram should appear as shown below:ī. Reading after this sequence should work correctly. Then, by using a VISA Flush I/O Buffer VI, you can clear any invalid data in the buffer. By putting a delay (approximately 10-100 ms) after the VISA Configure Serial Port VI, you allow the serial port enough time to configure itself. The port may not have completely finished its configuration by the time the first character is received off of that port. A framing error occurs when a byte of data is received, but it is not in the format expected. This kind of error may occur for several reasons:Ī. Each byte has a specific format with a start bit, data bits, parity, and stop bits. Serial data is transferred one byte at a time.